Table 3.

Cryptogenic Stroke Workup

Condition	Recommended Testing
Hypercoagulable disorder	CBC (hemoglobin and platelet count), factor V Leiden, protein C, protein S, antithrombin III, homocysteine levels, prothrombin G20210A mutation, and antiphospholipid antibodies
Paroxysmal atrial fibrillation	≥30‐day continuous cardiac monitoring
Cardiac thrombus, vegetation, or tumor; mitral stenosis	TTE followed by TEE (if TTE is normal); cardiac CT or MRI can be considered if high suspicion
Carotid atherosclerotic disease	Carotid duplex ultrasound, CTA, or MRA of the neck and head
Cerebral vascular atherosclerotic disease	CTA or MRA of the head
Aortic arch atheroma	TEE or CTA of the chest
Arterial dissection	CTA of the chest and neck
Cerebral venous sinus thrombosis	Brain MRV
May–Thurner syndrome	Pelvic MRV

Reprinted from Poulin et al51 with permission. Copyright ©2017, Bryn Mawr Communications. CBC indicates complete blood count; CTA, computed tomography angiography; MRA, magnetic resonance angiography; MRV, magnetic resonance venography; TEE, transesophageal echocardiography; TTE, transthoracic echocardiography.