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. 2018 Jun 15;7(12):e009388. doi: 10.1161/JAHA.118.009388

Figure 5.

Figure 5

Vascular expression of Nox5 induces endothelial dysfunction. A, Vascular relaxation to ACh assessed by wire myography in mesenteric arteries from WT (open circle), SM22+ (open triangle), Nox5+ (open rhombus), and Nox5+ SM22+ (open square). B, Vascular relaxation to ACh in arteries from WT (open circle), WT+Ang II (closed circle), Nox5+/SM22+ (open square), and Nox5+/SM22++Ang II (closed square) mice. C, Vascular relaxation to ACh assessed by wire myography in mesenteric arteries from WT (open circle), SM22+ (open triangle), and Nox5+ (open rhombus) before and after Ang II treatment (closed symbols). Results are mean±SEM of 5 to 8 mice/group. *P<0.05 vs WT; **P<0.05 vs untreated WT or Nox5+/SM22+ (open symbols). ACh indicates acetylcholine; Ang II, angiotensin II; Nox5, NADPH Oxidase 5; WT, wild‐type.