Table 2.
Hazard Ratios for All‐Cause Mortality (Beginning 30 days After Initial Heart Failure Diagnosis) by Baseline Serum Sodium Category in 24 517 Subjects With Heart Failure With Preserved Ejection Fraction Who Survived Past Day 30
| Serum Sodium (mmol/L) | Number of Deaths/Total Number of Subjects in Group | Person‐Time (y) | Crude HR (95% CI) | Age‐Adjusted HR (95% CI) | Multivariable HR (95% CI) |
|---|---|---|---|---|---|
| 115.00–134.99 | 1797/2717 | 9655.95 | 1.55 (1.47–1.63) | 1.59 (1.51–1.68) | 1.36 (1.28–1.44) |
| 135.00–137.99 | 2906/5046 | 21 831.45 | 1.12 (1.07–1.17) | 1.14 (1.09–1.20) | 1.06 (1.01–1.12) |
| 138.00–140.99 | 4936/9053 | 41 477.88 | REF | REF | REF |
| 141.00–143.99 | 3362/6041 | 28 482.09 | 0.99 (0.95–1.04) | 0.95 (0.91–0.99) | 0.99 (0.95–1.04) |
| 144.00–157.00 | 1009/1660 | 7535.83 | 1.13 (1.05–1.21) | 1.07 (1.00–1.14) | 1.09 (1.01–1.17) |
Multivariable model was adjusted for age; sex; race; body mass index; heart rate; estimated glomerular filtration rate; serum potassium; average LVEF; use of calcium channel blockers, angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers, and β‐blockers; and history of coronary artery disease, hypertension, hyperlipidemia, atrial fibrillation, chronic obstructive pulmonary disease, diabetes mellitus, and anemia. CI indicates confidence interval; HR, hazard ratio; LVEF, left ventricular ejection fraction; REF, referent group.