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. 2018 Oct 30;5(5):ENEURO.0397-17.2018. doi: 10.1523/ENEURO.0397-17.2018

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Copyright © 2018 Brimblecombe et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — Light activation of rat striatal cholinergic interneurons evokes striatal dopamine release. A, ChR2-eYFP detected in striatum (left) and PPN/LDT (right) after AAV2 injection to PPN/LDT (lower), and detected in striatum only after injection to striatum (upper), fixed tissue. B, GFP-immunopositive soma after striatal injection were co-immunopositive for ChAT. C, E, Mean profiles of [DA]_o ± SEM versus time evoked by 1 or 4 pulses (25 Hz) of electrical (C) or light (E) stimulation, in control drug-free conditions or in the presence of DHβE (1 μm). Data are normalized to 1p peak [DA]_o in control conditions. Control conditions (black lines), DHβE (red lines). D, F, Mean peak [DA]_o normalized to control 1p for electrical (D) and light-evoked DA release (F) in control (black) and in the presence of DHβE (red). n = 3 rats, n = 4 sites. Two-way ANOVA with Sidak posttest comparisons of control versus DHβE: *p < 0.05, ***p < 0.001.