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. 2018 Oct 31;9:2510. doi: 10.3389/fimmu.2018.02510

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Copyright © 2018 Winkel, Dalenberg, de Korne, Feijt, Langenberg, Pelgrom, Ganesh, Yazdanbakhsh, Smits, de Jong, Everts, van Leeuwen, Hokke and Roestenberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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S. mansoni cercariae do not induce DDC emigration from the skin. DDC gating strategy. Antigen presenting cells are selected by forward scatter (FSC) and side scatter (SSC) characteristics. Doublets are excluded (not shown). Live cells are gated and selected for the lack of lineage markers (CD56, CD3, CD19, CD20). APCs are selected on the expression of HLA-DR as well as intermediate to high levels of CD11c. HLA-DR⁺, CD11c⁺ cells can be divided into the different DDC populations: CD141⁺, LC, CD1a⁺ and CD14⁺ (A). Total emigrated HLA-DR⁺, CD11c⁺ antigen presenting cells from dermal biopsies at 3 days post exposure to S. mansoni cercariae or water control. Mean ± SEM, n = 7 (B). Subset distribution of emigrated cells (C).