Figure 6.

Stimulation with cercariae reduces pro-inflammatory potential of DDCs. Emigrated DDCs were co-cultured with CD4⁺ T cells to assess immunomodulatory potential. Data shown as percentages IFNγ or IL4 producing CD4⁺ T cells cultured with ex vivo stimulated DDCs relative to CD4⁺ T cells cultured with DDCs from untreated skin after PMA/ionomycin stimulation. Mean ± SEM. ^*p < 0.05, using paired Student's T-test (A). IL-10 production by CD4⁺ T cells after co-culture with DDCs. ELISA on culture supernatants after 24 h stimulation with anti CD3/28 (B). Data shown in pg/ml. Mean ± SEM.