Table 3. Results of the adjusted models for overall survival, local recurrence and disease free overall survival.

Outcome	Model	Variable	HR adjusted	CI (95%)		p
				inferior	superior
		Grade (ref.: I)
		II	2.38	0.45	12.74	0.310
	Initial	III	5.59	1.22	25.51	0.026
		Margins (positive)	0.98	0.39	2.48	0.970
Overall		Local Recurrence	6.94	1.79	26.99	0.005
Survival		Multiple Surgeries	0.47	0.14	1.55	0.214
		Grade (ref.:I)
	Final	II	2.54	0.48	13.41	0.271
		III	5.79	1.28	26.17	0.022
		Local Recurrence	3.72	1.54	8.97	0.003
		Margins (positive)	1.22	0.44	3.36	0.708
Local	Initial	Multiple Surgeries	18.82	4.35	81.38	<0.001
Recurrence		Metastasis	1.59	0.44	5.78	0.482
	Final	Margins (positive)	2.84	1.08	7.48	0.035
		Metastasis	6.59	2.17	20.02	0.001
		Grade (ref.: I)
		II	1.41	0.32	6.17	0.647
Disease		III	2.15	0.52	8.98	0.294
Free	Initial	Side (left)	0.75	0.30	1.90	0.546
Overall		Margins (positive)	0.82	0.32	2.07	0.668
Survival		Multiple Surgeries	3.91	1.55	9.86	0.004
		Metastasis	6.04	1.91	19.09	0.002
	Final	Multiple Surgeries	3.11	1.32	7.34	0.009
		Metastasis	8.17	2.68	24.92	<0.001

Cox multiple regression.