TABLE 3.

Multivariable Cox regression analysis for overall survival with recurrence locations as fixed covariates

Clinical characteristics	Multivariable analysis
	HR	95% CI	P-Value
Age at surgery, yearsa	1.01	1.01–1.02	< 0.001
Complicationsb
Clavien ≥ 3 versus Clavien ≤ 2	1.22	1.00–1.50	0.047
Tumor size, cma	1.11	1.05–1.17	< 0.001
Tumor differentiation grade
Poor vs. well/moderate	1.24	1.06–1.45	0.006
Microscopic perineural invasion
Yes versus no	1.24	0.93–1.66	0.147
Positive lymph node ratio
> 0.2 versus ≤ 0.2	1.49	1.26–1.76	< 0.001
Resection margin status
R1 versus R0	1.37	1.16–1.61	< 0.001
Adjuvant therapy
Adjuvant versus no adjuvant	0.61	0.52–0.72	< 0.001
Recurrence site
Multiple-site versus no recurrence	4.78	3.65–6.25	< 0.001
Liver-only versus no recurrence	5.75	4.39–7.55	< 0.001
Local-only versus no recurrence	2.46	1.86–3.24	< 0.001
Lung-only versus no recurrence	1.90	1.39–2.60	< 0.001
Other versus no recurrence	2.37	1.38–4.08	0.002

Significant values on multivariable analysis are shown in bold (P < 0.05)

HR hazard ratio, CI confidence interval

^aContinuous

^bAccording to the Clavien–Dindo classification