TABLE 4.

Multivariable Cox regression analysis for overall survival using a landmark set at 12 months post-surgery

Clinical characteristics	Multivariable analysis
	HR	95% CI	P-Value
Age at surgery, yearsa	1.02	1.01–1.02	0.001
Microscopic perineural invasion
Yes versus no	1.38	0.99–1.90	0.055
Positive lymph node ratio
> 0.2 versus ≤ 0.2	1.49	1.23–1.80	< 0.001
Resection margin status
R1 versus R0	1.28	1.06–1.55	0.012
Recurrence site
Multiple-site versus no recurrence	5.83	4.29–7.92	< 0.001
Liver-only versus no recurrence	5.77	4.21–7.92	< 0.001
Local-only versus no recurrence	3.61	2.67–4.88	< 0.001
Lung-only versus no recurrence	2.29	1.63–3.21	< 0.001
Other versus no recurrence	2.57	1.41–4.67	0.002

Significant values on multivariable analysis are shown in bold (P < 0.05)

HR hazard ratio, CI confidence interval

^aContinuous