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. Author manuscript; available in PMC: 2018 Dec 27.
Published in final edited form as: Nature. 2018 Jun 27;559(7712):67–72. doi: 10.1038/s41586-018-0255-3

Extended Data Figure 10. Transmembrane domain flexibility and comparison with reference structures.

Extended Data Figure 10

a-b, Top and side view of the TMD of conformation A with density for the γ2-subunit shown. c-d, As in a, but for conformation B. e, Transmembrane domain superposition of conformation A (subunits in color) over conformation B (gray). α-helices are represented as cylinders. f-j, Superposition of single subunit TMD in conformation A (colored) with its corresponding subunit in conformation B (gray). k-r, Superpositions of the 4 non-γ subunits. Top and bottom rows contain same superpositions in different representations. Conformation B is shown in all panels with α subunits in green and β subunits in blue. Reference structures include the glycine receptor with ivermectin bound (3JAF)77, GluCl with ivermectin bound (3RHW)78 and the GABA-A β3 homopentamer (4COF)16.