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. Author manuscript; available in PMC: 2018 Dec 27.
Published in final edited form as: Nature. 2018 Jun 27;559(7712):67–72. doi: 10.1038/s41586-018-0255-3

Figure 4. Pseudo-ligand sites vs. GABA and flumazenil sites.

Figure 4

a, Synaptic view, with colored boxes indicating the distinct pseudo-agonist sites. b,e, Detailed structural information of pseudo-agonist interfaces α-β and γ-β boxed in a. c,f, Superposition of GABA binding site (in gray) on α-β and γ-β interfaces respectively. d,g, Superposition of flumazenil binding site (in taupe) on the α-β and γ-β interfaces respectively. h, Sequence alignment of the loops involved in ligand binding pockets. Blue residues are involved in flumazenil binding; red residues are involved in GABA binding.