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. Author manuscript; available in PMC: 2018 Dec 27.
Published in final edited form as: Nature. 2018 Jun 27;559(7712):67–72. doi: 10.1038/s41586-018-0255-3

Figure 6. Conformational arrangements of transmembrane domain.

Figure 6

a,b Side and top views of the TM domain in conformation A. c,d, Side and top views of the TM domain in Conformation B. In b,d, putative cholesterol molecules are shown as sticks. Red arrows indicate sites that overlap with proposed endocannabinoid and pregnenolone sulfate (PS) sites. Blue arrows indicate sites shared with PS. Black arrows indicate sites shared with the neurosteroids pregnanolone and THDOC.