Fig. 4. Morphology and integrity of the alveolar-capillary barrier on the chip 24 hours after nanoparticle exposure (200 μg ml–1). A. TiO2-NPs’ effect on the expression of E-cadherin of HPAEpiCs; B. TiO2-NPs's effect on the expression of VE-cadherin of HUVECs; C. ZnO-NPs’ effect on the expression of E-cadherin of HPAEpiCs, red arrow indicates the disrupt on the epithelial barrier; D. ZnO-NPs’ effect on the expression of VE-cadherin of HUVECs. Dashed boxes indicate the epithelial or endothelial barrier structure on the chip. Scale bar: 100 μm.
