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. 2018 Jul 16;37(25):3661–3678. doi: 10.1002/sim.7842

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© 2018 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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sim7842-fig-0005 — Results from the Rotterdam Breast Cancer Study. Plots showing estimated log hazard ratios as a function of time from a complete‐data analysis, complete‐case analysis, and MI‐TVE‐SMC analysis. The time‐varying effects for all covariates were modelled using a restricted cubic spline with 5 knots. Shaded errors show 95% confidence intervals. Results are shown up to time 10. MI, multiple imputation; SMC, substantive‐model‐compatible; TVE, time‐varying effect [Colour figure can be viewed at http://wileyonlinelibrary.com]