Table 3.
Statistical Comparisons of Serum Pharmacokinetic Parameters of Caffeine After Administration of Products 1 and 2 to Healthy Male Subjects
| Product 1 | Product 2 | Products 1 and 2 | |||
|---|---|---|---|---|---|
| PK Parameters | n | GM | n | GM | GMR (90%CI) |
| Cmax, a μg/mL | 15 | 1.71 | 16 | 1.75 | 97.77 (81.90–116.71) |
| AUC0–4 h, a μg·h/mL | 15 | 5.51 | 16 | 5.60 | 98.33 (82.11–117.74) |
a
Back‐transformed least‐squares mean and confidence interval from ANOVA model performed on log‐transformed values.
GM, geometric least‐squares mean; GMR, geometric least‐squares mean ratio; CI, confidence interval.
GMR and 90%CI are reported as percentages.
Product 1, botanically sourced caffeine 60 mg derived from 480 mg of green coffee bean extract; product 2, synthetic US Pharmacopeia caffeine 60 mg.