Table 3.
Percentual changes in thrombin generation parameters of thrombomodulin‐modified thrombin generation testing in controls and patients with compensated (CC) or acutely decompensated cirrhosis (AD), or acute‐on‐chronic liver failure (ACLF) after in vitro addition of prohaemostatic agents
| ETP | Peak | Lag time | Vel index | |
|---|---|---|---|---|
| rFVIIa | ||||
| Controls | 21 (8‐32) | 20 (8‐32) | 28 (20‐34) | 20 (11‐42) |
| CC | 3 (0‐16)* | 2 (−3 to 9)** | 21 (20‐30) | 1 (−6 to 20)* |
| AD | 2 (−1 to 5)*** | −1 (−3 to 3)*** | 24 (17‐37) | 0 (−10 to 5)*** |
| ACLF | 3 (−3 to 27)* | −1 (−4 to 19)* | 20 (15‐25)* | 3 (−6 to 25) |
| Cofact | ||||
| Controls | 92 (788‐101) | 72 (46‐89) | 0 (0‐17) | 72 (38‐93) |
| CC | 109 (82‐149) | 89 (55‐102) | 0 (0‐0) | 78 (55‐104) |
| AD | 151 (135‐197)*** | 109 (87‐150)** | 0 (−13‐6) | 97 (75‐136)* |
| ACLF | 273 (212‐393)*** | 176 (141‐219)*** | 10 (0‐17) | 178 (156‐265)*** |
| Pooled normal plasma | ||||
| Controls | 16 (2‐21) | 15 (−3‐19) | 0 (−10‐0) | 15 (−4‐19) |
| CC | 7 (−1‐21) | 7 (0‐18) | 20 (0‐26) | 6 (−4‐18) |
| AD | 19 (8‐29) | 23 (10‐33) | −11 (−25‐0) | 22 (12‐31) |
| ACLF | 38 (27‐69) *** | 56 (47‐124) *** | 0 (−9‐9) | 59 (45‐117) *** |
Shown are the percentual increase of the ETP, peak, or velocity index, and the percentual decrease in the lag time. Data are expressed as median percentages with interquartile range.*P < .05, **P < .01, ***P < .001 vs controls.