TABLE 7. Incidence rates* and percentages† of invasive liver cancer, by demographic and tumor characteristics — United States,§ 2010–2014.
| Demographic characteristic | Total |
Male |
Female |
|||
|---|---|---|---|---|---|---|
| No. | Rate (95% CI) | No. | Rate (95% CI) | No. | Rate (95% CI) | |
|
Total
|
126,165
|
6.9 (6.8–6.9)
|
94,425
|
11.0 (10.9–11.0)
|
31,740
|
3.3 (3.2–3.3)
|
|
Age group at diagnosis (yrs)
| ||||||
| <40 |
2,589 |
0.3 (0.3–0.3) |
1,609 |
0.4 (0.4–0.4) |
980 |
0.2 (0.2–0.3) |
| 40–49 |
5,965 |
2.7 (2.6–2.8) |
4,660 |
4.3 (4.1–4.4) |
1,305 |
1.2 (1.1–1.3) |
| 50–59 |
37,661 |
17.0 (16.9–17.2) |
30,832 |
28.6 (28.3–29.0) |
6,829 |
6.0 (5.9–6.2) |
| 60–69 |
41,278 |
26.2 (25.9–26.4) |
32,632 |
43.3 (42.9–43.8) |
8,646 |
10.6 (10.3–10.8) |
| 70–79 |
23,722 |
27.2 (26.8–27.5) |
16,095 |
40.9 (40.3–41.5) |
7,627 |
15.9 (15.6–16.3) |
| ≥80 |
14,950 |
26.1 (25.7–26.5) |
8,597 |
40.1 (39.3–41.0) |
6,353 |
17.6 (17.1–18.0) |
|
Race
| ||||||
| White |
94,355 |
6.2 (6.1–6.2) |
70,871 |
9.8 (9.7–9.9) |
23,484 |
2.9 (2.9–3.0) |
| Black |
19,566 |
9.5 (9.3–9.6) |
14,820 |
16.0 (15.7–16.3) |
4,746 |
4.3 (4.2–4.4) |
| American Indian/Alaska Native |
1,463 |
9.0 (8.5–9.6) |
1,017 |
12.8 (12.0–13.7) |
446 |
5.6 (5.1–6.2) |
| Asian/Pacific Islander |
9,463 |
11.9 (11.7–12.2) |
6,734 |
18.5 (18.1–19.0) |
2,729 |
6.6 (6.3–6.8) |
|
Ethnicity¶
| ||||||
| Hispanic |
19,644 |
12.1 (11.9–12.3) |
14,334 |
18.7 (18.4–19.0) |
5,310 |
6.5 (6.3–6.7) |
| Non-Hispanic |
106,512 |
6.4 (6.4–6.4) |
80,084 |
10.3 (10.2–10.3) |
26,428 |
3.0 (3.0–3.0) |
|
County classification
| ||||||
| Metropolitan |
106,798 |
7.2 (7.1–7.2) |
79,865 |
11.5 (11.4–11.6) |
26,933 |
3.4 (3.4–3.5) |
| Nonmetropolitan |
15,220 |
5.8 (5.7–5.9) |
11,479 |
9.2 (9.0–9.4) |
3,741 |
2.8 (2.7–2.9) |
|
Census region
| ||||||
| Northeast |
23,350 |
6.8 (6.7–6.8) |
17,752 |
11.2 (11.0–11.3) |
5,598 |
3.0 (2.9–3.1) |
| Midwest |
22,601 |
5.6 (5.5–5.6) |
16,698 |
8.8 (8.6–8.9) |
5,903 |
2.8 (2.7–2.8) |
| South |
49,130 |
7.1 (7.1–7.2) |
37,028 |
11.5 (11.4–11.6) |
12,102 |
3.3 (3.3–3.4) |
| West |
31,084 |
7.9 (7.8–8.0) |
22,947 |
12.2 (12.1–12.4) |
8,137 |
4.0 (3.9–4.1) |
|
Tumor characteristic**
|
No.
|
%
|
No.
|
%
|
No.
|
%
|
|
Total
|
118,896
|
100.0
|
89,081
|
100.0
|
29,815
|
100.0
|
|
Histology
| ||||||
| Hepatocellular carcinoma |
102,719 |
86.4 |
79,381 |
89.1 |
23,338 |
78.3 |
| Adenocarcinoma |
8,584 |
7.2 |
4,890 |
5.5 |
3,694 |
12.4 |
| Epithelial carcinoma, NOS |
1,997 |
1.7 |
1,319 |
1.5 |
678 |
2.3 |
| All other histologies |
5,596 |
4.7 |
3,491 |
3.9 |
2,105 |
7.1 |
|
Stage††
| ||||||
| Localized |
53,260 |
44.8 |
39,105 |
43.9 |
14,155 |
47.5 |
| Regional |
32,202 |
27.1 |
24,977 |
28.0 |
7,225 |
24.2 |
| Distant |
18,662 |
15.7 |
14,421 |
16.2 |
4,241 |
14.2 |
| Unknown | 14,772 | 12.4 | 10,578 | 11.9 | 4,194 | 14.1 |
Abbreviations: CI = confidence interval; NOS = not otherwise specified.
* New cases diagnosed per 100,000 persons, age adjusted to the 2000 U.S. standard population.
† New cases diagnosed.
§ Cancer incidence data were compiled from cancer registries that met the data quality criteria for all invasive cancer sites combined, representing approximately 99% of the U.S. population. (Data from Nevada did not meet U.S. Cancer Statistics publication criteria for 2010–2014.)
¶ Ethnicity is not mutually exclusive from race.
** Excludes cases identified only through death certificate or autopsy reports.
†† Localized: cancer that is confined to the primary site; regional: cancer that has spread directly beyond the primary site or to regional lymph nodes; distant: cancer that has spread to other organs.