Table 1.

Parameters and their values

Parameter	Meaning	Value [95% CI]	Source
s	Target cell production rate	105 cells mL−1 day−1	14, 18
d T	Target cell death rate	0.01 day−1	39
β	Infectivity	1 × 10−8 mL cells−1 day−1	14, 18, 51
ω	Natural death rate of infected cells	0.01 day−1	ω = d T
λ	Effector cell recruitment rate	1 cells mL−1 day−1	36
b E	Antigen‐induced proliferation rate of effector cells	1 day−1
μ	Death rate of effector cells	2 day−1
k B	Hill function scaling for effector cell proliferation	103 cells mL−1	35, 36
n	Hill coefficient for exhaustion	>1
p	Production rate of virions by infected cells	4.4 virions cell−1 day−1	$p=\frac{d_T\mathrm{\delta }c}{s\mathrm{\beta }}\left(\frac{V_0\mathrm{\beta }}{d_T}+1\right)$
m	Killing rate of infected cells by effector cells	0.244 mL cells−1 day−1	$m=\frac{\mathrm{\delta }-\mathrm{\omega }}{E_0}$
δ	Death rate of infected cells	0.059 [0.026–0.092] day−1	Best‐fits (Figure 3a)a
ε	Efficacy of drugs	0.9991 [0.9988–0.9994]
c	Viral clearance rate	6.3 [5.8–6.8] day−1
d E	Antigen‐induced exhaustion rate of effector cells	4 day−1
k D	Hill function scaling for effector cell exhaustion	2.7 × 104 cells mL−1

^aFor the patient in Figure 3b, δ = 0.2 day⁻¹, d _E = 6 day⁻¹, k _D = 1.95 × 10³ cells mL⁻¹, p = 35.7 virions cell⁻¹ day⁻¹, and m = 1.36 mL cells⁻¹ day⁻¹.