Table 2.
Noncompartmental analysis derived pharmacokinetic parameters Cmax AUC0‐t, AUC0‐inf, Tmax and T1/2 from observed concentrations and individual Bayesian posterior final model predicted time‐observation profiles, per treatment
| Formulation 1 | Formulation 2 | Formulation 3 | Formulation 4 | |
|---|---|---|---|---|
| Cmax (mg/l) observed | 5.33 ± 1.79 | 5.43 ± 1.86 | 5.48 ± 1.44 | 5.62 ± 1.65 |
| Cmax (mg/l) predicted | 4.99 ± 1.71 | 4.87 ± 1.65 | 5.11 ± 1.36 | 5.16 ± 1.52 |
| AUC0‐t (h.mg/l) observed | 63.42 ± 25.72 | 61.55 ± 24.70 | 61.16 ± 20.80 | 62.08 ± 22.91 |
| AUC0‐t (h.mg/l) predicted | 59.92 ± 24.71 | 58.87 ± 24.01 | 58.88 ± 19.83 | 57.92 ± 22.04 |
| AUC0‐inf (h.mg/l) observed | 64.49 ± 25.68 | 62.39 ± 24.68 | 62.45 ± 20.88 | 63.03 ± 23.13 |
| AUC0‐inf (h.mg/l) predicted | 60.18 ± 24.62 | 59.12 ± 23.92 | 59.02 ± 19.87 | 58.29 ± 22.01 |
| Tmax (h) observed | 4.0 (2.50‐8.0) | 4.25 (2.0‐8.0) | 3.50 (1.5‐6.0) | 3.75 (1.5‐8.0) |
| Tmax (h) predicted | 3.5 (1.8‐8.8) | 3.7 (2.2‐6.4) | 3.0 (1.6‐6.2) | 3.7 (1.6‐6.0) |
| T1/2 (h) observed | 8.12 ± 2.70 | 8.08 ± 2.08 | 9.08 ± 3.63 | 7.66 ± 2.63 |
| T1/2 (h) predicted | 7.66 ± 5.94 | 7.92 ± 6.85 | 7.53 ± 4.25 | 12.24 ± 18.81 |
All parameters are mean ± SD, but Tmax median and range.