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. 2018 Aug 29;70(11):1853–1865. doi: 10.1002/art.40556

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© 2018 The Authors. Arthritis & Rheumatology published by Wiley Periodicals, Inc. on behalf of American College of Rheumatology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Transcriptional levels of B cell lymphoma 6 (Bcl‐6), B lymphocyte–induced maturation protein 1 (BLIMP‐1; PRDM1), and interleukin‐21 (IL‐21) in peripheral CD4+ T cells from patients with IgG4‐RD compared to healthy controls, and results of immunohistochemical staining of the involved tissue from patients. A and B, Levels of Bcl‐6 and BLIMP‐1 (PRDM1) mRNA in peripheral CD4+ T cells from patients with IgG4‐RD (A) and IL‐21 mRNA in peripheral CD4+ T cells from IgG4‐RD patients before and after treatment (B), compared to healthy controls. Results are the mean ± SD, calculated using the 2^–ΔΔCt method. C, Correlations between levels of IL‐21 mRNA and IgG4‐RD clinical indices. D, Specific staining of IL‐21, Bcl‐6, and IgG4 in the involved tissue from patients with IgG4‐RD. Original magnification × 100. See Figure 1 for other definitions.