Figure 2.

Hypoxia delays cellular fusion and with that osteoclastogenesis as indicated by the number of multinucleated, TRAP positive osteoclasts (OCL) over time (a) with representative examples (b), and corresponding results of the RT‐qPCR analysis of genes associated with osteoclast differentiation and function (c). TRAP, Tartrate‐resistant acid phosphatase, CA II, Carbonic Anhydrase II, CATK, Cathepsin K, DCSTAMP, Dendritic Cells (DC)‐Specific Transmembrane Protein, Integrin β3, Integrin subunit β3. Each symbol represents a single donor. *0.01 < p < 0.05; **p < 0.01 hypoxia vs normoxia at the same time point