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The senescence marker p21 is abundantly expressed during osteoclastogenesis and negatively affected by hypoxia. Percentage of p21 positive nuclei in multinucleated, TRAP positive osteoclasts (OCL) over time and representative examples (right) in normoxic (21% O2) and hypoxic (5% O2) culture conditions. The arrows indicate p21 positive nuclei in multinucleated cells. *0.01 < p < 0.05; **p < 0.01 hypoxia vs normoxia at the same time point
