Table 1.

Validation of the hub genes in the TCGA database

Hub gene	Methylation status	P value	Expression status	P value
Hypermethylation/low‐expression
PPARGC1A	Hypermethylation	.0039	Low expression	2.2 × 10−16
CREBBP	Hypermethylation	9.24 × 10−8	Low expression	8.15 × 10−10
EP300	Hypermethylation	3.24 × 10−6	Low expression	1.74 × 10−6
Hypormethylation/high‐expression
CD44	Hypomethylation	.0054	High expression	2.2 × 10−16
SPP1	Hypomethylation	.0087	High expression	6.59 × 10−5
MMP9	Hypomethylation	1.96 × 10−11	High expression	0.058

TCGA, the Cancer Genome Atlas.