Figure 8.
miR‐16 inhibits SSC‐25 engrafted tumor growth in vivo. SCC‐25 cells transfected with the miR‐16 mimic/inhibitor or scramble were injected into nude mice to generate a xenograft model. (a) Tumor size was measured every three days and calculated as length × width2/2. (b) Xenograft tumors were weighed on the 27th day after inoculating. (c) The relative miR‐16 expression in xenografts was analyzed by qRT‐PCR. (d) Protein expression of AKT3 in xenografts was measured by western blot. (e) Protein expression of BCL2L2 in xenografts was measured by western blot. Data were presented as mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001 versus the negative control. miR‐16, microRNA‐16; qRT‐PCR, quantitative reverse transcription polymerase chain reaction