Table 1.

Granuloma formation and eosinophilic crystal deposits in the lungs of 6–9‐week‐old wild‐type and Cyba ^tm1a mice

	Granulomas				Eosinophilic crystals
Genotype	Absent	Mild	Moderate	Severe	Absent	Present
Wild‐type	8/8	–	–	–	8/8	–
Cyba tm1a	4/8	2/8	1/8	1/8	4/8	4/8

Lungs from wild‐type and Cyba ^tm1a mice at 6–9 weeks of age were collected into 10% NBF and then histologically processed to allow assessment of an H&E‐stained slide containing a longitudinal section of all five lobes. The lungs were graded as mild, moderate or severe on the basis of the strongest phenotype seen in at least one of the five lobes. The grading of the severity of the eosinophilic granules present ‘matched’ that of the granulomas.