Table 4.
Cohort demographics separated by CD with active inflammation and CD without active inflammation
| Crohn's disease with CRP <5 mg/L N=81 | Crohn's disease with CRP >5 mg/L N=31 | P value | Healthy controls N=24 | P value | |
|---|---|---|---|---|---|
| General | |||||
| Gender n (%) female | 32 (39.5%) | 10 (32.3%) | .478 | 3 (12.5%) | .047 |
| Age at sample years, mean (minimum‐maximum) | 41.9 (18‐74) | 41.7 (19‐73) | .881 | 41.3 (19‐60) | .982 |
| Disease duration at sample years, mean (minimum‐ maximum) | 11.9 (0‐35) | 10.8 (1‐32) | .553 | NA | NA |
| Age at diagnosis n (%) | |||||
| A1, <16 years | 9 (11.1%) | 3 (9.7%) | .881 | NA | NA |
| A2, 17‐40 years | 57 (70.4%) | 21 (67.7%) | |||
| A3, >40 years | 15 (18.5% | 7 (22.6%) | |||
| Disease behavior n (%) | |||||
| Nonstricturing/nonpenetrating | 26 (32.1%) | 14 (45.2%) | .435 | NA | NA |
| Stricturing | 42 (51.9%) | 12 (41.9%) | |||
| Penetrating | 13 (16.0%) | 4 (12.9%) | |||
| Disease activity | |||||
| Clinical disease activity (HBI, % active disease (HBI≥5)) | 30 (37.0%) | 15 (48.4%) | .273 | NA | NA |
| Perianal disease n (%) | 19 (23.5%) | 9 (29.0%) | .542 | NA | NA |
| Smoking history n (%) | NA | NA | |||
| Current | 30 (37.0%) | 8 (25.8%) | .563 | NA | NA |
| Used to smoke | 21 (25.9%) | 10 (32.3%) | |||
| Never | 28 (34.6%) | 11 (35.5%) | |||
| Missing | 1 (1.2%) | 2 (6.4%) | |||
| Medication use n (%) | |||||
| 5‐aminosalycilates | 6 (7.4%) | 2 (6.5%) | .861 | NA | NA |
| Corticosteroids | 14 (17.3%) | 7 (22.6%) | .521 | NA | NA |
| Immunosuppressants | 51 (63.0%) | 14 (45.2%) | .088 | NA | NA |
| Anti‐Tumour Necrosis Factor alpha | 27 (33.3%) | 9 (29.0%) | .663 | NA | NA |
| Surgery n (%) | |||||
| Resection | 56 (69.1%) | 17 (54.8%) | .115 | NA | NA |
| Cause of resection | |||||
| Therapeutic resistance | 6 (7.4%) | 1 (3.2%) | .689 | NA | NA |
| Stenosis | 35 (43.2%) | 11 (35.5%) | |||
| Intra‐abdominal fistula/abscess | 9 (11.1%) | 2 (6.5%) | |||
| Stenosis and abscess/fistula | 4 (4.9%) | 1 (3.2%) | |||
| Other | 0 (0%) | 1 (3.2%) | |||
| Missing | 1 (1.2%) | 1 (3.2%) | |||
| Moment of resection | |||||
| Resection before sample | 45 (55.6%) | 14 (45.2%) | .154 | NA | NA |
| Resection after sample | 4 (4.9%) | 3 (9.7%) | |||
| Resection before and after sample | 7 (8.6%) | 0 (0%) | |||
| Re‐resection because of stenosis/intra‐abdominal fistula/abscess | 18 (22.2%) | 1 (3.2%) | .017 | NA | NA |
HBI, Harvey‐Bradshaw Index; NA, not applicable.
Nominal and continuous data were compared using ANOVA. P values depict statistical differences between patients with Crohn's disease and comparing patients with Crohn's disease to controls.