. 2018 May 18;32(10):1710–1727. doi: 10.1111/jdv.15019

Table 7.

Changes in safety laboratory values of relevant blood parameters in patients with psoriasis by treatment group within a period of 3 years; total number of patients with available data at baseline = 551

	Baseline	Month 3		Month 6		Month 12		Month 24		Month 36
	Mean ± SD [cells/μL]	Change^a [%]	P‐value^a	Change^a [%]	P‐value^a	Change^a [%]	P‐value^a	Change^a [%]	P‐value^a	Change^a [%]	P‐value^a
FAE monotherapy, n	390	365		329		269		156		99
Leucocytes	7314.0 ± 2207.3	−5.4	0.006	−13.0	<0.0001	−18.5	<0.0001	−16.4	<0.0001	−15.9	<0.0001
Lymphocytes	2005.3 ± 693.6	−19.4	<0.0001	−35.9	<0.0001	−40.3	<0.0001	−39.2	<0.0001	−42.8	<0.0001
Eosinophils	203.1 ± 175.5	176.8	<0.0001	33.4	0.0004	8.8	0.23	2.7	0.67	8.6	0.36
Platelets	261482.1 ± 79304.4	−3.5	0.0002	−4.6	<0.0001	−4.6	<0.0001	−4.4	0.002	−6.8	0.0006
FAEs + phototherapy, n	83	72		62		55		32		11
Leucocytes	7512.3 ± 2167.8	−13.8	<0.0001	−17.9	<0.0001	−22.6	<0.0001	−21.6	<0.0001	−18.6	0.02
Lymphocytes	1887.5 ± 618.9	−21.1	<0.0001	−35.9	<0.0001	−42.2	<0.0001	−36.2	<0.0001	−34.1	0.007
Eosinophils	194.9 ± 167.0	95.7	0.0006	16.1	0.24	3.8	0.77	−1.3	0.88	30.5	0.27
Platelets	245867.5 ± 62151.2	−2.6	0.10	−5.8	0.0002	−7.4	0.0002	−6.2	0.02	−9.5	0.06
FAEs + MTX, n	78	67		67		56		45		35
Leucocytes	8187.1 ± 2429.0	−14.0	<0.0001	−17.5	<0.0001	−18.7	<0.0001	−22.9	<0.0001	−19.9	0.0002
Lymphocytes	2056.4 ± 744.6	−20.2	0.0002	−32.8	<0.0001	−36.8	<0.0001	−32.9	<0.0001	−36.9	<0.0001
Eosinophils	212.8 ± 156.1	103.2	0.006	24.5	0.15	−4.5	0.67	1.6	0.88	−15.6	0.05
Platelets	258730.8 ± 75548.3	−4.4	0.02	−7.4	<0.0001	−8.8	<0.0001	−7.8	0.0007	−8.5	0.0007

FAEs, fumaric acid esters; phototherapy, ultraviolet A, ultraviolet B or psoralen + ultraviolet A; MTX, methotrexate; n, number of patients with available data; SD, standard deviation. Normal ranges: leucocytes = 4600−9500/μL, lymphocytes = 1000−4050/μL, eosinophils = 40−360/μL, platelets = 150 000−400 000/μL, SGOT = 10−50 IU/L, SGPT = 10−50 IU/L, GGT = 10−71 IU/L, serum creatinine = 0.70−1.20 mg/dL.

P‐value derived from one‐sample t‐test.

Mean percentage change from baseline