. 2018 May 18;32(10):1710–1727. doi: 10.1111/jdv.15019

Table 8.

Changes in safety laboratory values of relevant serum parameters in patients with psoriasis by treatment group within a period of 3 years; total number of patients with available data at baseline = 572

	Baseline	Month 3		Month 6		Month 12		Month 24		Month 36
	Mean ± SD	Change^b [%]	P‐value^a	Change^b [%]	P‐value^a	Change^b [%]	P‐value^a	Change^b [%]	P‐value^a	Change^b [%]	P‐value^a
FAE monotherapy, n	403	375		340		278		162		103
SGOT [IU/L]	23.2 ± 13.7	10.8	<0.0001	9.3	0.01	8.6	0.004	44.0	<0.0001	51.2	<0.0001
SGPT [IU/L]	28.2 ± 21.6	25.1	<0.0001	16.6	<0.0001	19.0	0.0005	38.2	0.008	38.3	0.001
GGT [IU/L]	38.1 ± 47.4	14.7	<0.0001	12.1	<0.0001	17.0	0.04	41.4	0.001	44.5	<0.0001
Creatinine [mg/dL]	0.92 ± 0.53	−0.2	0.93	−1.1	0.18	7.6	0.13	3.2	0.02	2.2	0.35
FAEs + phototherapy, n	89	75		66		55		33		13
SGOT [IU/L]	24.2 ± 13.3	11.4	0.02	0.3	0.95	8.8	0.15	28.8	0.01	36.5	0.08
SGPT [IU/L]	28.3 ± 19.4	25.0	0.0005	3.8	0.46	16.5	0.12	21.3	0.03	38.1	0.19
GGT [IU/L]	36.4 ± 31.3	4.8	0.18	9.1	0.09	17.6	0.13	6.9	0.57	9.0	0.66
Creatinine [mg/dL]	0.91 ± 0.29	1.4	0.70	0.9	0.81	7.1	0.11	7.5	0.005	7.6	0.37
FAEs + MTX, n	80	70		68		57		46		36
SGOT [IU/L]	25.5 ± 14.2	21.9	0.02	11.5	0.03	14.0	0.07	26.0	0.02	57.5	0.0007
SGPT [IU/L]	31.6 ± 19.3	54.0	0.003	28.0	0.002	22.3	0.05	27.6	0.03	63.8	0.002
GGT [IU/L]	42.6 ± 44.6	10.1	0.11	11.4	0.05	14.5	0.09	25.7	0.02	51.5	0.0007
Creatinine [mg/dL]	0.94 ± 0.19	−2.8	0.19	−3.2	0.05	−2.0	0.34	−1.1	0.64	−1.5	0.57

P‐value derived from one‐sample t‐test.

Mean percentage change from baseline.

FAEs, fumaric acid esters; phototherapy, ultraviolet A, ultraviolet B or psoralen + ultraviolet A; MTX, methotrexate; n, number of patients with available data; SD, standard deviation; SGOT, serum glutamic oxaloacetic transaminase; SGPT, serum glutamate pyruvate transaminase; GGT, gamma‐glutamyltransferase. Normal ranges: SGOT = 10−50 IU/L, SGPT = 10−50 IU/L, GGT = 10−71 IU/L, serum creatinine = 0.70−1.20 mg/dL.