Table 1.

This table summarizes evidences that CaMKII activity regulates memory destabilization

Authors (year)	Journal	Brain region	CaMKII manipulation	Behavioral phenotype
Cao et al. (2008)	Neuron	Forebrain	Over‐expression of αCaMKII‐F86G transgene and specific inhibition of αCaMKII‐F86G kinase activity	Retrieval‐dependent erasure of tone and contextual fear memory because of over‐expression; Phenotype reversed by blocking αCaMKII‐F86G ATP‐binding site
Jarome et al. (2016)	Neurobiol. Learn. Mem.	Amygdala	Pharmacological blocking of CaMKII with AIP	No effect on contextual fear memory alone; Rescued retrieval‐dependent fear memory impairment induced by protein synthesis blocking, suggesting blocking of memory destabilization by CaMKII blocking
Rossetti et al. (2017)	Neuron	Hippocampi	Viral‐induced expression of αCaMKII T286D/T305A/T306A	Impairment of previously learned place‐avoidance memory
Vigil et al. (2017)	Sci. Rep.	Dorsal‐hippocampi	Viral‐induced knock‐down of CaMKII endogenous inhibitor, CaMK2N1	Retrieval‐dependent impairment of contextual fear memory