Table 1.
Treatment*† | Aged 12 years or more | Aged less than 12 years |
---|---|---|
Magnesium sulfate (intravenous) | Twenty-four milligrams daily into three divided doses | Twelve milligrams daily into three divided doses |
If no convulsion within 12 hours, then 16 mg into two divided doses | If no convulsion within 12 hours, then 8 mg into two divided doses | |
If no convulsion within 24 hours, then 8 mg single dose | If no convulsion within 24 hours, then 4 mg single dose | |
Then if no convulsion state continues, then finally stop | Then if no convulsion state continues, then finally stop | |
Diazepam (intravenous with infusion) | Sixty milligrams daily into three divided doses | Thirty milligrams daily into three divided doses |
If able to take food by mouth, then 40 mg into two divided doses for 24 hours | If able to take food by mouth, then 20 mg into two divided doses for 24 hours | |
If improvement continues, then 20 mg once daily for 24 hours | If improvement continues, then 10 mg once daily for 24 hours | |
Finally, if improvement continues, then stop | Finally, if improvement continues, then stop | |
Immunotherapy (intramuscular) | Human TIG 500 units | Human TIG 250 units |
TT-containing vaccine, 0.5 mL | TT-containing vaccine, 0.5 mL | |
Antibiotics (intravenous) | Metronidazole intravenously 500 mg every 6 hours for 14 days | Metronidazole intravenously 250 mg every 6 hours for 14 days |
Ceftriaxone 2 gm intravenously daily for 14 days | One milligram intravenously daily for 14 days | |
Fluid (intravenous) | One liter 5% dextrose aqua daily during hospital stay | 0.5 L 5% dextrose aqua daily up to hospital staying |
Two liter dextrose in normal saline daily during hospital staying | One liter dextrose in normal saline daily during hospital stay |
Those who had no previous immunization history advised to complete a three-dose cycle of tetanus toxoid (TT)- tetanus toxoid immune globuline (TIG).
Discharged patients also advised to complete their antibiotic schedule.