Proteins differently expressed between AD and FTD. (A) a-beta-38 (untransformed data) and (B) pro-orexin are significantly altered between FTD from AD. (C) sTREM2 is elevated in both AD and FTD but there is no difference between the dementias. * indicates p < 0.05, ***p < 0.001, ****p < 0.0001 as determined by nonparametric Mann-Witney U analysis. Key: AD, Alzheimer's disease; FTD, frontotemporal dementia; sTREM2, soluble TREM2.