Table 2. Effects included in model M3 and their representation in the model’s design space.

MODEL COMPONENTS		DESIGN MATRIX
fixed effects	control factors	location + bone-vs-mold + rescan test
	experimental factors	+ log time + manufacture
	pairwise interactions	+ manufacture*log time + material*log time
	3-way interaction	+ manufacture*material*log time
random effects and error		+ lot + specimen + error