Table 6. Selected relevant metabolites to investigate the role of CD36 in GNP-induced macrophage responses.
| Metabolite Category | Metabolite | 50GNPs vs Ct | 100GNPs vs Ct | CD36 vs Ct | |||
|---|---|---|---|---|---|---|---|
| p-Value | Log FC | p—Value | Log FC | p—Value | Log FC | ||
| Pantothenate & CoA Biosynthesis | D-4'-Phosphopantothenate | 4.22E-08 | -18.71 | 2.38E-08 | -18.27 | 2.11E-08 | -18.13 |
| Pantetheine | 9.13E-07 | -17.55 | 8.63E-07 | -17.10 | 8.45E-07 | -16.97 | |
| Purine Metabolism | Guanine | 2.22E-07 | -17.30 | 1.77E-07 | -16.86 | 1.74E-07 | -16.73 |
| Cholic acid glucuronide | 1.12E-07 | -18.69 | 8.40E-08 | -18.24 | 7.71E-08 | -18.11 | |
| Phenylpropanoid biosynthesis | N1,N5,N10-Triferuloyl spermidine | 3.17E-07 | -17.88 | 2.73E-07 | -17.44 | 2.89E-07 | -17.31 |
| Argine and proline metabolism | N4-Acetylaminobutanal | 7.49E-06 | -17.70 | 7.83E-06 | -17.26 | 7.87E-06 | -17.13 |
| 2-deoxyecdysone 22-phosphate | 4.39E-08 | -17.10 | 2.14E-08 | -16.65 | 2.02E-08 | -16.52 | |
| Pyruvate metabolism | (R)-S-Lactoylglutathione | 9.64E-09 | -16.99 | 3.40E-09 | -16.52 | 3.32E-09 | -16.38 |
| Lysyl-Isoleucine | 3.54E-08 | -17.41 | 1.64E-08 | -16.97 | 1.22E-06 | 17.55 | |
| Glutathione Metabolism | γ-Glu-Cys | 8.03E-07 | 20.86 | 7.13E-08 | 20.21 | No Change | |
| Pyroglutamic acid | 2.63E-08 | 19.26 | 2.91E-08 | 20.38 | No Change | ||
| NADPH | 6.31E-06 | 17.75 | 2.87E-07 | 17.99 | No Change | ||
| S-Nitroso-L-glutathione | 1.46E-07 | -17.79 | 1.13E-07 | -17.34 | No Change | ||
| Pantothenate & CoA Biosynthesis | Pantothenic Acid | 1.83E-07 | 16.86 | 3.04E-07 | 17.44 | No Change | |
| Adenosine 3',5'-bisphosphate (PAP) | 5.56E-08 | 17.66 | 5.92E-08 | 18.44 | No Change | ||
| Arachidonic Acide Metabolism | 5S-HETE-d8 | 5.03E-06 | -18.32 | 5.31E-06 | -17.87 | No Change | |
| 20-hydroxy-LTE4 | 7.57E-08 | 17.15 | 6.99E-08 | 17.69 | No Change | ||
| Purine Metabolism | Uric acid | 2.86E-04 | -2.08 | 2.23E-04 | -2.67 | No Change | |
| Riboflavin Metabolism | Riboflavin (Vitamin B2) | 6.35E-05 | 2.50 | 6.01E-08 | 17.06 | No Change | |
| Lumichrome | 8.57E-08 | 17.17 | 4.63E-08 | 18.29 | No Change | ||
| Valyl-Gamma-glutamate | 1.23E-08 | -20.10 | 4.01E-09 | -19.65 | No Change | ||
| Skimate/acetate-malonate pathway derived compounds | Isobatatasin I | 1.43E-08 | -16.99 | 3.08E-09 | -16.55 | No Change | |
| CPA(18:0/0:0) | 3.21E-06 | 17.07 | 4.47E-07 | 17.23 | No Change | ||
| Prolyl-Lysine | 9.14E-08 | 17.27 | 1.51E-07 | 18.02 | No Change | ||
| Limonene and pinene degradataion Degradation of aromatic compounds |
3-Isopropenylpimelyl-CoA | No Change | 4.11E-08 | 18.14 | 1.27E-07 | 17.52 | |
| Naphthalene degradation Microbial metabolism in diverse environments Degradation of aromatic compounds |
2-Naphthoyl-CoA | No Change | 3.86E-08 | 18.16 | 1.06E-06 | 17.58 | |
| Toluene Degradation | 3-Hydroxybenzaldehyde | No Change | No Change | 4.40E-09 | -20.49 | ||
| Glutathione Metabolism | Glutathione, oxidized | No Change | No Change | 9.15E-06 | -19.85 | ||
| Purine Metabolism | XMP (Xanthosine monophosphate) | No Change | No Change | 2.86E-08 | -18.30 | ||
| Tyrosyl-Aspartate | No Change | No Change | 5.13E-07 | 17.30 | |||
| S-Decyl GSH | No Change | No Change | 6.11E-06 | 17.53 | |||
| 8-Hydroxyadenine | No Change | No Change | 1.94E-08 | 22.34 | |||
Note: Ct: control; 50GNPs: 50 μg/mL GNPs; 100GNPs: 100 μg/mL GNPs; FC: fold change.