Table 1. Comparison of results of controlled ovarian stimulation (initiated cycles) for patients with AMH <1.2 ng/mL between the GnRH agonist (GnRH-a) and antagonist (GnRH-ant) protocols.
Women Age | ≤35 | 36~39 | ≥40 | |||
Criteria | POSEIDON group 3 | POSEIDON group 4 | POSEIDON group 4, Bologna criteria | |||
Group | PG3 | PG4A | PG4B | |||
Protocols | GnRH-a | GnRH-ant | GnRH-a | GnRH-ant | GnRH-a | GnRH-ant |
Initiated ART cycles | 283 | 54 | 352 | 73 | 311 | 160 |
Age (years) | 33.0±1.9 | 33.4±1.6 | 37.6±1.1 | 37.4±1.2 | 42.3±2.2 | 42.6±1.8 |
Height (cm) | 159.2±5.0 | 159.6±5.4 | 159.5±5.5 | 159.8±5.7 | 159.3±5.3 | 159.3±5.5 |
Weight (Kg) | 55.4±8.1 | 55.6±9.1 | 56.3±9.0 | 55.9±10.3 | 57.2±8.0 | 56.9±7.3 |
BMI (Kg/M2) | 21.9±3.1 | 21.7±2.7 | 22.1±3.3 | 21.9±3.5 | 22.5±3.1 | 22.5±2.8 |
Basal FSH (IU/L) | 10.2±5.5 | 9.7±5.5 | 10.9±6.5 | 9.6±5.4 | 11.5±6.4 | 10.9±6.0 |
AMH (ng/mL) | 0.65±0.24 | 0.58±0.24 | 0.61±0.26 | 0.57±0.28 | 0.57±0.26 | 0.54±0.26 |
E2 on hCG day (pg/mL) | 677±468 | 711±413 | 637±506 | 685±450 | 533±447 | 575±452 |
P4 on hCG day (ng/mL) | 1.00±2.58 | 0.89±0.75 | 1.02±4.65 | 1.33±3.08 | 1.23±6.15 | 1.26±2.85 |
LH on hCG day (IU/L) | 2.63±3.07a | 3.71±3.58a | 2.79±3.85 | 3.74±4.89 | 4.36±7.98b | 6.61±7.81b |
rFSH total dose (IU) | 3298±670c | 3018±939 c | 3533±938 | 3324±946 | 4319±1075d | 3937±1054d |
ET cancellation (%) | 30 (10.6) e | 12 (22.2) e | 67 (19.0) | 18 (24.7) | 91 (29.3) | 41 (25.9) |
No oocyte retrieved (%) | 9(3.2) | 3 (5.6) | 17 (4.8) | 6 (8.2) | 29 (9.3) | 19(9.9) |
No mature oocytes (%) | 6 (2.1) | 4 (7.4) | 16 (4.5) | 1 (1.4) | 17 (5.5) | 7(4.3) |
No embryos (%) | 15 (5.3) | 5 (9.3) | 34 (9.7) | 12 (16.4) | 45 (14.5) | 15(9.9) |
ET rate (%) | 253(89.4) | 42 (77.8) | 285(81.0) | 55 (75.3) | 220 (70.7) | 119 (74.1) |
Data are presented as mean ± SD or number (percentage). For the percentage, the numerator is the number of cycles with ET cancellation, no oocyte retrieved, no mature oocytes, or no embryos; and the denominator is the number of initiated cycles.
a, p = 0.021;
b, p = 0.003;
c, p = 0.009;
d, p<0.001 by Student’s t test; and
e, p = 0.018 by the chi-squared test.