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. 2018 Nov 7;13(11):e0207081. doi: 10.1371/journal.pone.0207081

Table 1. Comparison of results of controlled ovarian stimulation (initiated cycles) for patients with AMH <1.2 ng/mL between the GnRH agonist (GnRH-a) and antagonist (GnRH-ant) protocols.

Women Age ≤35 36~39 ≥40
Criteria POSEIDON group 3 POSEIDON group 4 POSEIDON group 4, Bologna criteria
Group PG3 PG4A PG4B
Protocols GnRH-a GnRH-ant GnRH-a GnRH-ant GnRH-a GnRH-ant
Initiated ART cycles 283 54 352 73 311 160
Age (years) 33.0±1.9 33.4±1.6 37.6±1.1 37.4±1.2 42.3±2.2 42.6±1.8
Height (cm) 159.2±5.0 159.6±5.4 159.5±5.5 159.8±5.7 159.3±5.3 159.3±5.5
Weight (Kg) 55.4±8.1 55.6±9.1 56.3±9.0 55.9±10.3 57.2±8.0 56.9±7.3
BMI (Kg/M2) 21.9±3.1 21.7±2.7 22.1±3.3 21.9±3.5 22.5±3.1 22.5±2.8
Basal FSH (IU/L) 10.2±5.5 9.7±5.5 10.9±6.5 9.6±5.4 11.5±6.4 10.9±6.0
AMH (ng/mL) 0.65±0.24 0.58±0.24 0.61±0.26 0.57±0.28 0.57±0.26 0.54±0.26
E2 on hCG day (pg/mL) 677±468 711±413 637±506 685±450 533±447 575±452
P4 on hCG day (ng/mL) 1.00±2.58 0.89±0.75 1.02±4.65 1.33±3.08 1.23±6.15 1.26±2.85
LH on hCG day (IU/L) 2.63±3.07a 3.71±3.58a 2.79±3.85 3.74±4.89 4.36±7.98b 6.61±7.81b
rFSH total dose (IU) 3298±670c 3018±939 c 3533±938 3324±946 4319±1075d 3937±1054d
ET cancellation (%) 30 (10.6) e 12 (22.2) e 67 (19.0) 18 (24.7) 91 (29.3) 41 (25.9)
No oocyte retrieved (%) 9(3.2) 3 (5.6) 17 (4.8) 6 (8.2) 29 (9.3) 19(9.9)
No mature oocytes (%) 6 (2.1) 4 (7.4) 16 (4.5) 1 (1.4) 17 (5.5) 7(4.3)
No embryos (%) 15 (5.3) 5 (9.3) 34 (9.7) 12 (16.4) 45 (14.5) 15(9.9)
ET rate (%) 253(89.4) 42 (77.8) 285(81.0) 55 (75.3) 220 (70.7) 119 (74.1)

Data are presented as mean ± SD or number (percentage). For the percentage, the numerator is the number of cycles with ET cancellation, no oocyte retrieved, no mature oocytes, or no embryos; and the denominator is the number of initiated cycles.

a, p = 0.021;

b, p = 0.003;

c, p = 0.009;

d, p<0.001 by Student’s t test; and

e, p = 0.018 by the chi-squared test.