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. 2018 Oct 26;14(10):e1007404. doi: 10.1371/journal.ppat.1007404

Fig 1. The polyamine biosynthetic pathway in T. brucei.

Fig 1

L-Met, L-methionine; AdoMetSyn, S-adenosylmethionine synthetase; AdoMet, S-adenosylmethionine; AdoMetDC, S-adenosylmethionine decarboxylase; prozyme, AdoMetDC pseudoenzyme required for activity; dcAdoMet, decarboxylated S-adenosylmethionine; L-Orn, L-ornithine; ODC, ornithine decarboxylase; PUT, putrescine; SPD, spermidine; SpdSyn, spermidine synthase; TryS, trypanothione synthetase; T[SH]2, trypanothione; DHS, deoxyhypusine synthase composed of two inactive paralogs in the trpanosomatids DHSc and DHSp; DOHH, deoxyhypusine hydroxylase; eIF5A, eukaryotic initiation factor 5A; dh-eIF5A, deoxyhypusine eIF5A; GSH, glutathione.