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. 2018 Sep 6;37(12):1579–1585. doi: 10.1097/ICO.0000000000001756

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 3. — Fenretinide inhibited Aspergillus fumigatus-induced production of IL-1β through blockade of the LOX-1/JNK pathway in the mice cornea. A, After fenretinide pretreatment, mRNA expression of LOX-1 was significantly downregulated in A. fumigatus-infected mouse corneas (n = 6/group) at 1 day after infection. B, mRNA expression of IL-1β was also downregulated. C, Compared with infected controls, LOX-1, phosphorylated JNK, and pro-IL-1β protein levels in corneas were significantly lower at 1 day after infection in fenretinide-pretreated mice. JNK protein levels were not affected by fenretinide pretreatment (P > 0.05). The mean values and SDs of 2 independent experiments are shown.