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. 2018 Sep 6;37(12):1579–1585. doi: 10.1097/ICO.0000000000001756

FIGURE 5.

FIGURE 5.

Fenretinide pretreatment increased apoptosis in mouse Aspergillus fumigatus keratitis. A, mRNA levels of Bcl-2 were not affected by fenretinide pretreatment (P > 0.05) (n = 6/group). B–F, Compared with infection controls, the mRNA levels of BAX (P < 0.01), cytochrome c (P < 0.05), cleaved-caspase-8 (P < 0.05), cleaved-caspase-9 (P < 0.05), and cleaved-caspase-3 (P < 0.05) in fenretinide-pretreated mice corneas were significantly increased. G, BAX, cytochrome c, cleaved-caspase-8, cleaved-caspase-9, and cleaved-caspase-3 protein levels in fenretinide-pretreated mice corneas were found to be significantly increased (P < 0.01, respectively); however, Bcl-2 levels were not affected by fenretinide pretreatment (P > 0.05). Mean values and SDs from 2 independent experiments are shown.