Table 1 –

Serum analysis.

	Phosphate (mg/dl)	Calcium (mg/dl)	Alk. Phos. (mg/dl)	Creatinine (mg/dl)	FGF-23 (mg/dl)
Wild-type control	12.0 ± 1.3	9.5 ± 0.3	241.7 ± 34.6	0.2 ± 0.0	180 ± 54
	n = 14	n = 14	n = 16	n = 14	n = 6
Phex control	8.1 ± 1.3*	9.2 ± 0.6	747 ± 109.5 +	0.2 ± 0.0	1840 ± 223 ^
	n = 13	n = 11	n = 13	n = 11	n = 6
Phex prevention	8.6 ± 1.1**	8.8 ± 0.4	647.6 ± 99.6 ++	0.2 ± 0.0	2934 ± 883 ^^,!
	n = 6	n = 5	n = 5	n = 4	n = 3
Phex rescue	9.9 ± 1.5***	8.3 ± 0.4 #,⌘	566.8 ± 72.1 +++,‡	0.2 ± 0.1	3239 ± 718 ^^^,†
	n = 5	n = 6	n = 6	n = 6	n = 2

Data are expressed as mean ± SD. Serum samples were collected at P40.

Statistics calculated with a one-way ANOVA using multiple comparisons. Alk. Phos. = alkaline phosphatase. CI = 95% confidence interval of the mean differences. FGF-23 = fibroblast growth factor-23.

^*p < 0.0001 Phosphate wild-type control vs. Phex control (CI: 2.5 to 5.3).

^**p = 0.0001 Phosphate wild type vs. Phex prevention (CI: 1.5 to 5.3).

^***p = 0.003 Phosphate wild type vs. Phex rescue (CI: 0.8 to 4.6).

^#p < 0.0001 Calcium wild-type control vs. Phex rescue (CI: 0.6 to 1.7).

^⌘p = 0.002 Calcium Phex prevention vs. Phex rescue (CI: 0.3 to 1.5). −585 to −426).

⁺p < 0.0001 Alk. Phos. wild-type control vs. Phex control (CI: −546 to −307).

⁺⁺p < 0.0001 Alk. Phos. wild-type control vs. Phex prevention (CI: −427 to −223).

⁺⁺⁺p < 0.0001 Alk. Phos. wild-type control vs. Phex rescue (CI: −2379 to −941).

^‡p = 0.0003 Alk. Phos. Phex control vs. Phex rescue (CI: 74.8 to 285).

^{^}p < 0.0001 FGF-23 wild-type control vs. Phex control (CI: −3635 to −1874).

^{^^}p < 0.0001 FGF-23 wild-type control vs. Phex prevention (CI: −4076 to −2043).

^{^^^}p < 0.0001 FGF-23 wild-type control vs. Phex rescue (CI: −1975 to −214).

^!p = 0.014 FGF-23 Phex control vs. Phex prevention (CI: −2416 to −383).

^†p = 0.007 FGF-23 Phex control vs. Phex rescue (CI:−2416 to-383).