Figure 3. Incidence of multiple phenotypes, including parent-reported wheeze.

(A) Physician-diagnosed asthma (B) defined wheeze phenotypes (C) in relation to food and inhalant sensitisation (D) stratified by cluster and time in the CAS dataset. Points indicate observed proportion; bars indicate 95% CI (binomial distribution). Wheeze phenotypes defined as: no wheeze = no wheeze at ages 1 to 3, or age 5; transient wheeze = any wheeze at ages 1 to 3, but not age 5; late wheeze = wheeze at age 5, but not ages 1 to 3; persistent wheeze = any wheeze at both ages 1 to 3 and age 5. Food sensitisation defined as peanut IgE ≥0.35 kU/L at any age, or cow’s milk, egg white, peanut SPT > 2 or 3 mm for age ≤2 or>2 respectively. Inhalant sensitisation defined as HDM, cat, couchgrass, ryegrass, mould or Phadiatop IgE ≥0.35 kU/L at any age, or mould SPT (Alternaria or Aspergillus spp.)>2 or 3 mm for age ≤2 or>2, respectively.

Figure 3—figure supplement 1. Relationship of clusters to food sensitisation, eczema and wheeze.

Percentages denote proportion of cluster displaying phenotype (numbers in brackets denote actual sample numbers). Food sensitisation defined as peanut IgE ≥0.35 kU/L at any age, or cow’s milk, egg white, peanut SPT > 2 or 3 mm for age ≤2 or>2, respectively. Subphenotypes defined for food sensitisation, eczema and wheeze as: no phenotype = phenotype absent at all ages; transient = any incidence of phenotype at the earlier ages (1 to 3 for wheeze, 6 m to three for eczema, 6 m to two for sensitisation), but not age 5; late = phenotype at age 5, but not the earlier ages; persistent = any incidence of phenotype at both earlier ages and age 5.