Figure 5. LRI frequency (A), wheezy LRI (wLRI) frequency (B), and HDM IgE (C), stratified by age-5 wheeze status, cluster and time, in the CAS dataset.
Points indicate means; bars indicate 95% CI (t-distribution). #p<0.05 for repeated-measures ANOVA across timepoints from the first 3 years of life (see Table 4). *p<0.05 for Mann-Whitney-Wilcoxon comparison within each timepoint.
Figure 5—figure supplement 1. A ‘simple’ decision tree generated by recursive partitioning from CAS data, with breakdown of tree clusters by actual CAS npEM-derived clusters.
(A); scatterplot showing separation of CAS clusters by decision split thresholds (B). Percentages in Panel A may not sum up to 100% because some individuals have missing values for decision node variables, hence making them impossible to classify. In Panel B, note that left-most column of points represent values of HDM IgG4 that were less than the limit-of-detection (LOD) for that assay (0.0003 μg/L) and were subsequently assigned to half the LOD (0.00015 μg/L). Most of these points belonged to individuals from CAS1.
Figure 5—figure supplement 2. Decision tree generated by recursive partitioning from CAS data, excluding Phadiatop assay variables.
Figure 5—figure supplement 3. A ‘comprehensive’ decision tree generated by recursive partitioning from CAS data, given CAS npEM-derived clusters and age-5 wheezing status.
CAS1.x, 2.x, and 3.x, and tree cluster 1.x, 2.x and 3.x, refer to the intersection of npEM-generated clusters and age-5 wheeze status, and their analogous decision tree cluster, respectively. The second digit (x.0 or x.1) refers to age-5 wheeze status, with ‘1’=present wheeze and ‘0’=no wheeze. Boxes, bars and digits with red outline indicate those with predicted (tree cluster) or actual (CAS npEM cluster) age-5 wheeze. Note that the tree did not predict for non-wheezing CAS3, so there is no tree cluster 3.0, and all CAS3 individuals were automatically assigned to a wheezing tree cluster.
Figure 5—figure supplement 4. Comparison of predictors for age-5 wheeze in CAS and COAST clusters.
Colour coding and numbers in cells indicate odds ratio (OR) of predictor for age-5 wheeze in GLM, with sex, maternal and paternal history of asthma, and (for CAS) BMI as covariates. Non-grey cell with number indicates statistically significant association (p<0.05). Grey cell with number indicates non-significant (p>0.05); grey non-numbered cell indicates test not done due to lack of data.