Table 1.
Characteristics of Subjects Included in Study
| Normative Aging Study |
COPDGene Study |
|||
|---|---|---|---|---|
| Characteristic | Baseline | Last Visit | Baseline | 5-Year Follow-up |
| n | 1,060 | 1,060 | 3,546 | 1,802 |
| Visit No. | 1 | 6.3 ± 2.4 | 1 | 2 |
| Age, yr | ||||
| Mean ± SD | 42.2 ± 8.6 | 68.9 ± 8.6 | 62.3 ± 8.8 | 68.0 ± 8.2 |
| Range | 24.7–77.2 | 45.1–91.6 | 45.0–81.0 | 47.0–86.8 |
| FEV1 | ||||
| Mean ± SD, L | 3.8 ± 0.6 | 2.6 ± 0.7 | 2.5 ± 1.0 | 2.4 ± 0.9 |
| Range, L | 0.7–6.1 | 0.7–4.9 | 0.3–5.5 | 0.4–5.1 |
| % of predicted value | 116.2 ± 15.8 | 104.8 ± 32.1 | 72.6 ± 26.4 | 75.2 ± 25.6 |
| FVC | ||||
| Mean ± SD, L | 4.8 ± 0.7 | 3.6 ± 0.7 | 3.9 ± 1.0 | 3.7 ± 0.9 |
| Range, L | 2.5–6.6 | 1.6–6.3 | 1.2–7.7 | 1.2–7.1 |
| % of predicted value | 88.2 ± 10.8 | 93.0 ± 14.5 | 85.3 ± 18.2 | 85.7 ± 17.8 |
| FEV1/FVC, % | ||||
| Mean ± SD | 79 ± 7 | 72 ± 21 | 63 ± 17 | 64 ± 16 |
| Range | 17.6–98.8 | 17.6–92.8 | 15.0–94.0 | 17.0–92.0 |
| BMI, kg/m2 | ||||
| Mean ± SD | 25.7 ± 2.9 | 27.9 ± 4.0 | 28.8 ± 5.5 | 29.1 ± 5.5 |
| Range | 16.0–38.4 | 15.8–52.3 | 13.8–58.6 | 16.7–58.6 |
| Pack-years | ||||
| Mean ± SD | 29.0 ± 17.9 | 40.3 ± 24.0 | 50.6 ± 25.8 | 49.6 ± 24.8 |
| Range | 0.0–117.0 | 10.0–145.4 | 10.0–150.0 | 10.0–146.8 |
| Height, cm | ||||
| Mean ± SD | 175.9 ± 6.4 | 173.2 ± 6.5 | 176.1 ± 6.9 | 175.7 ± 6.8 |
| Range | 153.9–194.1 | 148.5–191.3 | 138.9–200.3 | 152.0–199.4 |
| Current smoker, No./total No. (%) | 603/1,060 (57) | 188/1,060 (18) | 1,427/3,546 (40) | 471/1,802 (26) |
Definition of abbreviations: BMI = body mass index; COPDGene = Genetic Epidemiology of COPD Study.