Table 2.
Characteristics of COPDGene Subjects by Trajectory Assignment Stratified by Age*
| 45–55 Years Old |
55–65 Years Old |
|||||||
|---|---|---|---|---|---|---|---|---|
| T1 | T2 | T3 | T4 | T1 | T2 | T3 | T4 | |
| n | 98 | 272 | 361 | 96 | 243 | 411 | 545 | 82 |
| FEV1, % pred | 41.1 ± 10 | 73.3 ± 10 | 94.4 ± 8 | 110.2 ± 7 | 34 ± 10 | 66.2 ± 10 | 91.8 ± 10 | 112 ± 10 |
| FEV1, L | 1.60 ± 0.59 | 2.82 ± 0.49 | 3.68 ± 0.43 | 4.45 ± 0.38 | 1.21 ± 0.46 | 2.33 ± 0.55 | 3.24 ± 0.42 | 3.93 ± 0.40 |
| FVC, % pred | 69 ± 20 | 83.5 ± 10 | 95.9 ± 10 | 108.4 ± 8 | 65.8 ± 20 | 80.7 ± 10 | 95 ± 10 | 111.1 ± 10 |
| FVC, L | 3.46 ± 1.0 | 4.13 ± 0.8 | 4.82 ± 0.7 | 5.63 ± 0.6 | 3.07 ± 0.9 | 3.75 ± 0.8 | 4.44 ± 0.6 | 5.17 ± 0.6 |
| FEV1/FVC | 0.47 ± 0.14 | 0.69 ± 0.10 | 0.77 ± 0.06 | 0.79 ± 0.05 | 0.40 ± 0.12 | 0.63 ± 0.13 | 0.74 ± 0.07 | 0.76 ± 0.06 |
| Height, cm | 177.2 ± 7 | 176.1 ± 7 | 177.3 ± 7 | 179.7 ± 6 | 175.9 ± 7 | 176 ± 7 | 176.4 ± 7 | 176.2 ± 7 |
| BMI, kg/m2 | 27.8 ± 6 | 29.4 ± 7 | 28.2 ± 5 | 26.8 ± 4 | 28.1 ± 6 | 29.9 ± 6 | 28.9 ± 5 | 28.2 ± 4 |
| Pack-years | 44.3 ± 20 | 40.5 ± 20 | 38 ± 20 | 41.4 ± 20 | 52.2 ± 20 | 54.3 ± 30 | 46.4 ± 20 | 53.6 ± 30 |
| Pi10 | 3.75 ± 0.2 | 3.68 ± 0.1 | 3.61 ± 0.1 | 3.58 ± 0.1 | 3.74 ± 0.2 | 3.66 ± 0.1 | 3.59 ± 0.1 | 3.56 ± 0.1 |
| Perc15, HU | −939.7 ± 30 | −910 ± 20 | −912.4 ± 20 | −919.9 ± 20 | −950.3 ± 30 | −922.1 ± 30 | −920 ± 20 | −922.9 ± 20 |
| BODE | 3.73 | 1.06 | 0.36 | 0.28 | 4.24 | 1.40 | 0.28 | 0.22 |
| MMRC | 2.42 | 1.32 | 0.65 | 0.48 | 2.63 | 1.41 | 0.52 | 0.44 |
| Exacerbations | 0.91 | 0.35 | 0.10 | 0.05 | 0.97 | 0.45 | 0.10 | 0.06 |
| 6MWD, m | 378 ± 122 | 456 ± 110 | 492 ± 103 | 511 ± 98 | 358 ± 117 | 427 ± 115 | 490 ± 107 | 502 ± 109 |
| 65–75 Years Old |
75–85 Years Old |
|||||||
|---|---|---|---|---|---|---|---|---|
| T1 | T2 | T3 | T4 | T1 | T2 | T3 | T4 | |
| n | 235 | 459 | 412 | 46 | 39 | 141 | 93 | 13 |
| FEV1, % pred | 30.6 ± 10 | 55.9 ± 10 | 89.4 ± 10 | 111.5 ± 10 | 32.9 ± 8 | 57.5 ± 20 | 90.7 ± 10 | 114.3 ± 7 |
| FEV1, L | 0.99 ± 0.36 | 1.76 ± 0.54 | 2.84 ± 0.45 | 3.76 ± 0.45 | 0.95 ± 0.27 | 1.59 ± 0.47 | 2.53 ± 0.43 | 3.31 ± 0.28 |
| FVC, % pred | 64.3 ± 10 | 76.8 ± 10 | 93.7 ± 10 | 110 ± 10 | 69 ± 20 | 80.3 ± 20 | 93.7 ± 10 | 107.4 ± 8 |
| FVC, L | 2.82 ± 0.7 | 3.26 ± 0.7 | 4.04 ± 0.6 | 5.02 ± 0.6 | 2.76 ± 0.8 | 3.10 ± 0.6 | 3.65 ± 0.6 | 4.35 ± 0.4 |
| FEV1/FVC | 0.35 ± 0.10 | 0.54 ± 0.14 | 0.71 ± 0.08 | 0.75 ± 0.06 | 0.35 ± 0.08 | 0.52 ± 0.13 | 0.70 ± 0.10 | 0.77 ± 0.05 |
| Height, cm | 177 ± 7 | 174.7 ± 7 | 175.7 ± 7 | 179.1 ± 7 | 175.7 ± 6 | 173.8 ± 7 | 174.5 ± 7 | 176.8 ± 5 |
| BMI, kg/m2 | 27.2 ± 5 | 29.5 ± 6 | 29.4 ± 5 | 28 ± 4 | 26.9 ± 5 | 28.5 ± 5 | 28.9 ± 5 | 29.4 ± 5 |
| Pack-years | 52 ± 20 | 63.3 ± 30 | 55.3 ± 30 | 55.2 ± 20 | 42.1 ± 20 | 54.2 ± 30 | 54.1 ± 30 | 49.7 ± 20 |
| Pi10 | 3.76 ± 0.1 | 3.68 ± 0.1 | 3.59 ± 0.1 | 3.57 ± 0.1 | 3.78 ± 0.2 | 3.70 ± 0.2 | 3.62 ± 0.1 | 3.54 ± 0.1 |
| Perc15, HU | −959.5 ± 20 | −936.6 ± 30 | −925.2 ± 20 | −930.6 ± 10 | −962.6 ± 20 | −940 ± 20 | −927.8 ± 20 | −930.1 ± 10 |
| BODE | 4.57 | 2.16 | 0.31 | 0.04 | 4.59 | 1.98 | 0.22 | 0.15 |
| MMRC | 2.65 | 1.59 | 0.61 | 0.15 | 2.74 | 1.57 | 0.51 | 0.31 |
| Exacerbations | 0.76 | 0.52 | 0.15 | 0.07 | 0.82 | 0.49 | 0.29 | 0.00 |
| 6MWD, m | 301 ± 115 | 399 ± 113 | 461 ± 101 | 512 ± 87 | 301 ± 109 | 365 ± 100 | 415 ± 98 | 459 ± 96 |
Definition of abbreviations: % pred = percentage of the predicted value; 6MWD = 6-minute-walk distance; BMI = body mass index; BODE = body mass index, airflow obstruction, dyspnea, and exercise capacity index; COPDGene = Genetic Epidemiology of COPD Study; HU = Hounsfield units; MMRC = modified Medical Research Council; Perc15 = HU value representing the 15th percentile of the lung region HU histogram; Pi10 = internal lumen perimeter of 10 mm.
*
Values represent means ± SD.