Table 3.

Heritability and Family History of Respiratory Disease in COPDGene Subjects Stratified by Lung Function Trajectory

Characteristic*	T1 (n = 615 [17%])	T2 (n = 1,283 [36%])	T3 (n = 1,411 [40%])	T4 (n = 237 [7%])	P Value†
					T1 vs. T2	T1 vs. T3	T1 vs. T4	T2 vs. T3	T2 vs. T4	T3 vs. T4
Father, emphysema	127/333	192/764	174/937	28/150	0.002	<0.001	0.002	0.01	0.21	0.93
	(27.6%)	(20.1%)	(15.7%)	(15.7%)
Mother, emphysema	87/411	124/914	123/1,078	10/188	0.004	<0.001	<0.001	0.22	0.006	0.03
	(17.5%)	(11.9%)	(10.2%)	(5.1%)
Father, COPD	75/364	106/802	87/968	12/150	0.008	<0.001	0.004	0.01	0.14	0.83
	(17.1%)	(11.7%)	(8.2%)	(7.4%)
Mother, COPD	74/424	79/920	82/1,086	8/186	<0.001	<0.001	<0.001	0.48	0.09	0.18
	(14.9%)	(7.9%)	(7.0%)	(4.1%)
Father, chronic bronchitis	44/379	70/820	61/1,002	7/167	0.16	0.002	0.02	0.08	0.1	0.46
	(10.4%)	(7.9%)	(5.7%)	(4.0%)
Mother, chronic bronchitis	45/440	87/926	94/1,088	10/188	0.73	0.43	0.09	0.64	0.12	0.2
	(9.3%)	(8.6%)	(8.0%)	(5.1%)
Father, asthma	29/412	44/880	43/1,062	6/172	0.21	0.03	0.17	0.39	0.54	0.9
	(6.6%)	(4.8%)	(3.9%)	(3.4%)
Mother, asthma	30/454	75/942	51/1,135	8/189	0.47	0.13	0.36	0.003	0.13	0.97
	(6.2%)	(7.4%)	(4.3%)	(4.1%)
Heritability‡					0.02 (0.14 ± 0.18)	0.003 (0.51 ± 0.18)	0.02 (0.83 ± 0.40)	0.2 (0.10 ± 0.12)	0.2 (0.17 ± 0.22)	0.04 (0.33 ± 0.20)

Definitions of abbreviations: COPD = chronic obstructive pulmonary disease; COPDGene = Genetic Epidemiology of COPD Study.

^*Proportions given are of those with versus those without (with/without). Percentages indicate the percentage of those with relative to all respondents [100 × with/(with + without)].

^†P values are based on Pearson’s χ² test.

^‡Values in parentheses: narrow sense heritability (quantifies the proportion of phenotypic variance that can be explained by genetic variance under an additive genetic model).