Table 1.
Demographic and Clinical Characteristics of the Cohort
| All Subjects (n = 85) | Healthy (n = 10) | Disease (n = 36) | Lung Cancer (n = 39) | P Value* | |
|---|---|---|---|---|---|
| Age, yr | 61.2 ± 13.6 | 42.1 ± 13.6 | 60.7 ± 12.2 | 66.2 ± 9.2 | ns† |
| Sex, male | 63 (48) | 90 (9) | 56 (20) | 69.2 (27) | ns |
| Race | |||||
| White | 52.9 (45) | 50 (5) | 56 (20) | 51.3 (20) | ns |
| Black | 17.6 (15) | 30 (3) | 5.6 (2) | 25.6 (10) | 0.024† |
| Asian | 10.6 (9) | 0 | 8.1 (3) | 15.4 (6) | ns† |
| Hispanic | 11.8 (11) | 10 (1) | 22.2 (8) | 5.1 (2) | 0.024† |
| Other | 5.9 (5) | 10 (1) | 8.1 (3) | 2.6 (1) | ns† |
| Smoking status | |||||
| Current smoker | 28.9 (22) | 0 | 30.6 (11) | 30.8 (12) | ns |
| Past smoker | 56.6 (43) | 0 | 50.0 (18) | 66.7 (26) | ns† |
| Never smoker | 14.5 (11) | 100 (10) | 19.4 (7) | 2.6 (1) | 0.019† |
| Pack-years | 30.9 ± 30.0 | 0 | 29.3 ± 25.2 | 41.83 ± 32.1 | ns† |
| Diagnosis | |||||
| Non–lung cancer | 54.1 (46) | ||||
| Healthy | 100 (10) | ||||
| Benign NOS‡ | 66.7 (24) | ||||
| Infection | 6.5 (3) | ||||
| Lymphoma | 4.3 (2) | ||||
| Organizing PNA | 2.2 (1) | ||||
| Sarcoidosis | 2.2 (1) | ||||
| TB | 6.5 (2) | ||||
| Other | 2.2 (1) | ||||
| Lung cancer | 45.9 (39) | ||||
| Adeno | 56.4 (22) | ||||
| Squamous | 25.6 (10) | ||||
| Small cell | 12.8 (5) | ||||
| Carcinoma NOS | 5.1 (2) |
Definition of abbreviations: NOS = not otherwise specified; ns = not significant; PNA = pneumonia; TB = tuberculosis.
Data are presented as % (n) or mean ± SD.
*
P values based on Mann-Whitney U or chi-square (continuous or categorical variables, respectively) comparing lung cancer versus disease control.
†
Significant (P value < 0.05) differences on the basis of Kruskal-Wallis test comparing all three groups.
‡
NOS indicates clinically diagnosed as non–lung cancer; however, no specific diagnosis made.