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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Expert Rev Neurother. 2017 Oct 30;17(12):1167–1177. doi: 10.1080/14737175.2017.1395700

Figure 2.

Figure 2.

Rho-associated coiled-coil kinase (ROCK) protein structure and activation. (a) The ROCK proteins are composed of an amino terminal domain (N-terminal) followed by a coiled-coil region with Rho binding domain (RBD). The carboxy-terminal (C-terminal) region contains pleckstrin homology domain (PH) and a cysteine-rich region. (b) Inactivation of ROCK by intermolecular association of C-terminal and kinase domain, Rho-GTP dependent activation and conformational change, and Rho independent activation by ROCK cleavage.