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. 2018 Nov 1;9:1418. doi: 10.3389/fphys.2018.01418

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Copyright © 2018 Lozier, Kopchick and de Lacalle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in strength and phenotype. (A) Quantification of hind limb grip strength in each experimental group. GHR^-/- mice (n = 9) were significantly stronger than controls (n = 7), and bGH mice (n = 7) were significantly weaker than controls (n = 5), ^∗p < 0.05. (B) Quantification of body weight change in each experimental group. GHR^-/- mice (n = 9) weighed significantly less than controls (n = 7) and bGH mice (n = 7) weighed significantly more than controls (n = 5), ^∗p < 0.05. (C) Quantification of percent lean mass change in each experimental group. GHR^-/- mice (n = 9) had significantly reduced percent lean mass, compared to controls (n = 7), and bGH mice (n = 7) had significantly increased percent lean mass, compared to controls (n = 5), ^∗p < 0.05.