Table 3.
Mean Difference (95% CI) in Arsenic Metabolism by One Carbon Metabolism-Related Genetic Polymorphisms (N=935)
| Variable | n | iAs% | MMA% | DMA% |
|---|---|---|---|---|
| CBS (rs12482221) | ||||
| AA | 365 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| AG | 409 | 0.15(−0.7, 0.99) | −0.18 (−0.89, 0.52) | 0.04(−1.28, 1.36) |
| GG | 161 | −0.42 (−1.62, 0.79) | −0.29 (−1.23, 0.66) | 0.70(−1.12, 2.52) |
| SHMT1 (rs12952556) | ||||
| AA | 637 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| AG | 269 | 0.42(−0.51, 1.36) | 0.03(−0.67, 0.72) | −0.45 (−1.75, 0.84) |
| GG | 29 | 0.80(−1.63, 3.23) | 1.54(−0.64, 3.73) | −2.35 (−6.56, 1.87) |
| SHMT1 (rs2273027) | ||||
| AA | 286 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| AG | 463 | 0.51(−0.42, 1.45) | −0.21 (−1.04, 0.62) | −0.31 (−1.82, 1.21) |
| GG | 186 | 0.00(−1.18, 1.19) | −0.33 (−1.31, 0.64) | 0.33(−1.50, 2.15) |
| PEMT (rs4646371) | ||||
| GG | 360 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| GA | 452 | −0.44 (−1.35, 0.47) | 0.18(−0.56, 0.92) | 0.26(−1.13, 1.65) |
| AA | 123 | −0.47 (−1.89, 0.94) | 0.08(−0.99, 1.15) | 0.39(−1.74, 2.52) |
| MTRR (rs3776464) | ||||
| AA | 513 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| AT | 358 | 0.13(−0.79, 1.06) | 0.25(−0.43, 0.93) | −0.38 (−1.75, 0.98) |
| TT | 64 | 0.01(−1.72, 1.75) | 0.25(−1.72, 1.75) | −0.26 (−3.09, 2.57) |
| MTRR (rs16879334) | ||||
| CC | 586 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| CG | 306 | 0.13(−0.79, 1.06) | 0.28(−0.41, 0.96) | −0.41 (−1.78, 0.95) |
| GG | 43 | 0.01(−1.72, 1.75) | 0.26(−1.28, 1.80) | −0.27 (−3.10, 2.55) |
| MTHFR (1801131) | ||||
| CC | 586 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| CT | 306 | 0.07(−0.85, 0.98) | −0.28 (−1.02, 0.46) | 0.21(−1.17, 1.60) |
| TT | 43 | −1 (−2.84, 0.85) | −0.97 (−2.46, 0.52) | 1.97(−0.46, 4.39) |
| MTHFR (1801133) | ||||
| AA | 473 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| AC | 394 | 0.07(−0.73, 0.87) | 0.42(−0.29, 1.13) | −0.49 (−1.79, 0.81) |
| CC | 68 | 1.18(−0.62, 2.98) | 1.02(−0.42, 2.46) | −2.20 (−4.82, 0.43) |
| MTHFR (2274976) | ||||
| GG | 790 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| GA/AA | 145 | −0.89 (−2.03, 0.25) | −0.75 (−1.68, 0.18) | 1.64(−0.10, 3.39) |
| MTHFD1 (rs3818239) | ||||
| AA | 838 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| AG/GG | 77 | −1.08 (−2.32, 0.15) | −0.40 (−1.42, 0.62) | 1.48(−0.38, 3.34) |
| MTHFD1 (rs17751556) | ||||
| AA | 870 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| AG | 97 | −0.32 (−2.00, 1.35) | 0.65(−0.76, 2.06) | −0.32 (−3.05, 2.40) |
| MTR (rs10495387) | ||||
| CC | 892 | 0.00(Reference) | 0.00(Reference) | 0.00(Reference) |
| CA/AA | 43 | 1.51(−0.64, 3.66) | 2.57(0.22, 4.92) | −4.08 (−8.32, 0.17) |
Models adjusted for age, sex, ΣAs, 4 genetic PCs
Abbreviations: DMA (dimethylarsinic acid); iAs (inorganic arsenic); monomethylarsonic acid (MMA)