. Author manuscript; available in PMC: 2019 Dec 1.

Published in final edited form as: Environ Int. 2018 Oct 12;121(Pt 1):728–740. doi: 10.1016/j.envint.2018.09.048

Table 6.

Association Between MTR and Diabetes-Related Outcomes Before and After Adjustment for Arsenic Metabolism

	Final Model	Final Model + MMA% & ΣAs adjustment
*MTR rs10495387*
RR of Incident Diabetes (N=1458)
CC	1	1
CA/AA	0.67 (0.30, 1.50)	0.70(0.31, 1.60)
GMR of HOMA2-IR (N=1458)
CC	1	1
CA/AA	0.79 (0.66, 0.93)	0.83(0.71, 0.99)
Mean Difference in Waist Circumference (N=1458)
CC	Reference	Reference
CA/AA	−0.03 (−4.01, 3.94)	1.35(−2.51, 5.21)
RR of Incident Metabolic Syndrome (N=935)
CC	1	1
CA/AA	0.84 (0.54, 1.32)	0.93(0.58, 1.48)

All models adjusted for age, sex and 4 population stratification PCs

Abbreviations: ΣAs (sum of iAs, MMA and DMA); GMR (geometric mean ratio); HOMA2-IR (homeostasis model assessment for insulin resistance); MMA (monomethylarsonic acid); RR (relative risk)