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. 2018 Nov 1;8:467. doi: 10.3389/fonc.2018.00467

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Copyright © 2018 Boons, Vandamme, Peeters, Beyens, Driessen, Janssens, Zwaenepoel, Roeyen, Van Camp and Op de Beeck.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Copy number variation (CNV) profiles with correlations (Pearson's r) of tumor tissue and cell-free DNA (cfDNA) samples of the two metastatic cases. CNV profiles of tumor tissue and cfDNA were created respectively by whole-exome sequencing (WES) and shallow whole-genome sequencing (sWGS). (A) CNV profiles of case 7, with from top to bottom the CNV profile of tumor tissue, perioperative cfDNA sample (T1) and follow-up cfDNA sample, 23 months later (T1+23). (B) CNV profiles of case 3 (top: tumor tissue; bottom: cfDNA).