Table 1 –
Subject characteristics
| Lean | Obese | |
|---|---|---|
| n (F/M) | 16 (7/9) | 17(8/9) |
| Age (years) | 33.0 ± 2.5 | 31.5 ± 2.5 |
| Weight (kg) | 68.5 ± 2.6 | 98.5± 3.5*** |
| BMI (kg/m2) | 23.3 ± 0.6 | 34.2 ± 0.7*** |
| Body fat mass (%) | 22.5 ± 2.2 | 34.2 ± 1.6*** |
| FFM (kg) | 52.9 ± 2.4 | 64.8 ± 2.7** |
| VO2max (ml·min−1) | 2086 ± 164 | 2286 ± 134 |
| VO2max (ml·kgFFM−1·min−1) | 39.1 ± 2.0 | 35.3 ± 1.5 |
| Waist circumference (cm) | 80.1 ± 1.9 | 106.7 ± 3.2*** |
| Hip circumference (cm) | 98.1 ± 1.8 | 118.1 ± 2.6*** |
| Waist-to-hip ratio | 0.82 ± 0.02 | 0.91 ± 0.03** |
| Fasting plasma glucose (mg·dl−1) | 87.4 ± 1.6 | 91.4 ± 3.5 |
| Fasting plasma insulin (ulU·ml−1) | 5.0 ± 0.8 | 11.1 ± 1.2*** |
| HOMA-IR | 1.1 ±0.2 | 2.6 ± 0.3*** |
| Matsuda-ISI | 10.1 ± 1.5 | 4.2 ± 0.8** |
| HbA1c (mmol·mol−1) | 34.2 ± 0.5 | 36.2 ± 0.6* |
| HbAlc (%) | 5.2 ± 0.1 | 5.5 ± 0.1* |
| TSH (mIU·l−1) | 2.1 ± 0.4 | 2.4 ± 0.3 |
| Plasma triglycerides (mg·dl−1) | 86.6 ± 13.6 | 133.1 ± 20.1 |
| Total plasma cholesterol (mg·dl−1) | 170.9 ± 9.3 | 177.3 ± 6.5 |
| Plasma HDL-Cholesterol (mg·dl−1) | 61.3 ± 3.9 | 46.5 ± 2.9** |
| Plasma LDL-Cholesterol (mg·dl-1) | 92.3 ± 7.8 | 104.3 ± 6.3 |
Values are mean ± SEM. BMI, body mass index; FFM, fat-free mass; VO2max, maximal oxygen uptake; HOMA-IR, homeostatic model assessment of insulin-resistance; Matsuda-ISI, Matsuda insulin-sensitivity index; HbA1c, glycated hemoglobin; TSH, thyroid-stimulating hormone; HDL, high-density lipoprotein; LDL, low-density lipoprotein;
*
P ≤ 0.05,
**
P ≤ 0.01,
***
P ≤ 0.001 significantly different from lean subjects.